The cutaneous side-effects of hydroxyurea

被引：22
|
作者：
Young, HS
Khan, ASA
Kendra, JR
Coulson, IH
机构：
[1] Burnley Gen Hosp, Dept Dermatol, Burnley BB10 2PQ, Lancs, England
[2] Burnley Gen Hosp, Dept Haematol, Burnley BB10 2PQ, Lancs, England
来源：
CLINICAL AND LABORATORY HAEMATOLOGY | 2000年 / 22卷 / 04期
关键词：
hydroxyurea; hydroxyurea dermopathy; skin malignancy; nonscarring alopecia; longitudinal melanonychia;
D O I：
10.1046/j.1365-2257.2000.00311.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The cutaneous side-effects of long-term hydroxyurea therapy are not widely known and only rarely reported. We report on a patient who developed widespread skin changes, including the recently recognized hydroxyurea dermopathy, during long-term treatment with hydroxyurea for polycythaemia rubra vera. The time course of the clinical changes suggests that they result from direct toxicity of hydroxyurea on the basal layer of the epidermis and mucosal surfaces. We aim to increase clinical awareness of this problem.
引用
收藏
页码：229 / 232
页数：4
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