Epigenetic Regulation of Cancer Immune Cells

被引：12
|
作者：
Patino, Diego M. Avella [1 ,2 ]
Radhakrishnan, Vijay [1 ]
Suvilesh, Kanve N. [1 ]
Manjunath, Yariswamy [1 ,2 ]
Li, Guangfu [1 ,2 ]
Kimchi, Eric T. [1 ,2 ,4 ]
Staveley-O'Carroll, Kevin F. [1 ,2 ,4 ]
Warren, Wesley C. [1 ,3 ,4 ]
Kaifi, Jussuf T. [1 ,2 ,4 ]
Mitchem, Jonathan B. [1 ,2 ,4 ]
机构：
[1] Ellis Fischel Canc Ctr, Dept Surg, Columbia, MO USA
[2] Harry S Truman Mem Vet Hosp, Columbia, MO USA
[3] Univ Missouri, Bond Life Sci Ctr, Columbia, MO USA
[4] Washington Univ, Sch Med, Siteman Canc Ctr, St Louis, MO USA
来源：
SEMINARS IN CANCER BIOLOGY | 2022年 / 83卷
关键词：
Epigenetics; Tumor infiltrated immune cells; DNA methylation; Histone modification and antitumor immunity; TUMOR-ASSOCIATED MACROPHAGES; CD8(+) T-CELLS; HISTONE DEACETYLASES; GENE-EXPRESSION; NK CELLS; DNA METHYLATION; KEY REGULATOR; STATE; CHEMOIMMUNOTHERAPY; INFLAMMATION;
D O I：
10.1016/j.semcancer.2021.06.022
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The epigenetic regulation of immune response involves reversible and heritable changes that do not alter the DNA sequence. Though there have been extensive studies accomplished relating to epigenetic changes in cancer cells, recent focus has been shifted on epigenetic-mediated changes in the immune cells including T cells, Macrophages, Natural Killer cells and anti-tumor immune responses. This review compiles the most relevant and recent literature related to the role of epigenetic mechanisms including DNA methylation and histone modifications in immune cells of wide range of cancers. We also include recent research with respect to role of the most relevant transcription factors that epigenetically control the anti-tumor immune response. Finally, a statement of future direction that promises to look forward for strategies to improve immunotherapy in cancer.
引用
收藏
页码：377 / 383
页数：7
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