Histamine H3 receptor agonists

被引：12
|
作者：
De Esch, IJP [1 ]
Belzar, KJ [1 ]
机构：
[1] De Novo Pharmaceut, Cambridge CB4 9ZR, England
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 09期
关键词：
Histamine; H-3; GPCR; agonist; isoform; activity; efficacy; affinity;
D O I：
10.2174/1389557043403134
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The SAR of H-3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H-3 agonists that has been described in literature to date.
引用
收藏
页码：955 / 963
页数：9
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