Maternal nicotine exposure during gestation and lactation induces cardiac remodeling in rat offspring

被引：15
|
作者：
Chou, Hsiu-Chu [1 ]
Chen, Chung-Ming [2 ,3 ]
机构：
[1] Taipei Med Univ, Coll Med, Sch Med, Dept Anat & Cell Biol, Taipei, Taiwan
[2] Taipei Med Univ, Coll Med, Sch Med, Dept Pediat, Taipei, Taiwan
[3] Taipei Med Univ Hosp, Dept Pediat, Taipei, Taiwan
来源：
REPRODUCTIVE TOXICOLOGY | 2014年 / 50卷
关键词：
Nicotine; Myosin heavy chain; Collagen; Transforming growth factor-beta 1; GROWTH-FACTOR-BETA; CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS; COTININE CONCENTRATIONS; EXPRESSION PATTERNS; SMOKING MOTHERS; GENE-EXPRESSION; PASSIVE SMOKING; VITAMIN-E; HEART;
D O I：
10.1016/j.reprotox.2014.09.013
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aim of this study was to evaluate the effects of maternal nicotine exposure on heart morphology and fibrosis in rat offspring. Nicotine was administered to pregnant Sprague-Dawley rats by using a subcutaneous osmotic mini-pump at a dose of 6 mg/kg/day from Gestational Days 7-21 or Gestational Day 7 to Postnatal Day 14.A control group received an equal volume of saline by the same route as nicotine. Rats born to prenatal nicotine-treated dams exhibited significantly greater cell width of cardiomyocytes, fewer cardiomyocyte nuclei number, higher beta-myosin heavy chain and transforming growth factor (TGF-beta 1) expression, and higher collagen deposition in heart compared with rats born to normal saline-treated dams on Postnatal Days 7 and 21. Postnatal nicotine exposure further enhances these effects. We conclude that TGF-beta 1 may be involved in the pathogenesis of cardiac remodeling induced by maternal nicotine exposure during gestation and lactation in rat offspring. (C) 2014 Elsevier Inc. All rights reserved.
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页码：4 / 10
页数：7
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