1D saturation transfer difference NMR experiments on living cells:: The DC-SIGN/oligomannose interaction

被引：72

作者：

Mari, S ^{[1
]}

Serrano-Gómez, D ^{[1
]}

Cañada, FJ ^{[1
]}

Corbí, AL ^{[1
]}

Jiménez-Barbera, J ^{[1
]}

机构：

[1] CSIC, Ctr Invest Biol, Dept Inmunol & Estructura Prot, E-28040 Madrid, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 02期

关键词：

drug design; molecular recognition; NMR spectroscopy; proteins; receptors;

D O I：

10.1002/anie.200461574

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

SIGN of the times: Receptor-ligand interactions in which integral membrane proteins are involved can be detected directly by 1D saturation transfer difference (STD) NMR experiments on living cells (see 1H NMR (a) and STD (b) spectra of mannan with K562-CD209 cells). The technique can be used for molecular recognition in drug-screening processes and is demonstrated for the DC-SIGN receptor.

引用

页码：296 / 298

页数：3

共 24 条

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