We describe two new species of Pleroma (Melastomataceae) from the state of Espirito Santo, Brazil. Pleroma fragae can be recognized by the combination of glabrous styles and both cycles of stamens that have glandulose connectives. This species also has an arboreal habit, hypanthium and sepals that are hispid-strigose and eglandulose, and subisomorphic stamens, with filaments that have glandular trichomes. Pleroma leopoldinensis can be recognized by the glabrous adaxial surface of the leaves (except on the nerves), non-confluent veins, well developed, apical inflorescences, and glabrous hypanthia, filaments, connectives and styles. In addition, the ovary has five appendages on its apex, these covered with eglandular trichomes. Both species are endemic to Espirito Santo, and both grow in vegetation associated with inselbergs, but P. leopoldinensis can also be found in open vegetation along roadsides. We provide a map, drawings, photos and conservation status assignments for both species.