STRUCTURE-ACTIVITY RELATIONSHIPS OF SYNTHESIZED PROCYANIDIN OLIGOMERS: DPPH RADICAL SCAVENGING ACTIVITY AND MAILLARD REACTION INHIBITORY ACTIVITY

被引：5

作者：

Saito, Akiko ^{[1
]}

Nakajima, Noriyuki ^{[1
,2
]}

机构：

[1] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

[2] Toyama Prefectural Univ, Fac Engn, Dept Biotechnol, Toyama 9390398, Japan

来源：

HETEROCYCLES | 2010年 / 80卷 / 02期

基金：

日本学术振兴会;

关键词：

Condensed Tannin; Antioxidant; Tea Catechin; Polyphenol; Artificial Procyanidin Oligomer; HIGHLY STEREOSELECTIVE-SYNTHESIS; EQUIMOLAR CONDENSATION; CATECHIN CONDENSATION; ANTIOXIDANT ACTIVITY; SYSTEMATIC SYNTHESIS; EFFICIENT SYNTHESIS; 3,4-TRANS CATECHIN; PROANTHOCYANIDINS; FLAVONOIDS; GLYCATION;

D O I：

10.3987/COM-09-S(S)88

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Procyanidins are known as condensed tannins and/or oligomeric flavonoids, and are present in many edible plants and show interesting various biological activities. We previously developed and reported a simple and versatile method of synthesizing procyanidin oligomers consisting of (-)-epicatechin and (+)-catechin. Here, we report the structure activity relationships (SAR) between the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity and Mail lard reaction inhibitory activities of various procyanidin oligomers synthesized, including dimers, trimers, tetramers, pentamers, 3-O-substituted oligomers, and other artificial oligomers.

引用

页码：1081 / 1090

页数：10

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