Neuropsychiatric Symptoms in Parkinson's Disease

被引：347

作者：

Aarsland, Dag ^{[1
,2
,3
]}

Marsh, Laura ^{[4
,5
,6
]}

Schrag, Anette ^{[7
]}

机构：

[1] Stavanger Univ Hosp, Norwegian Ctr Movement Disorders, N-4068 Stavanger, Norway

[2] Univ Bergen, Dept Clin Med, Bergen, Norway

[3] Kings Coll London, Inst Psychiat, London WC2R 2LS, England

[4] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Neurol & Neurol Sci, Baltimore, MD USA

[6] Johns Hopkins Univ, Sch Med, Morris K Udall Parkinsons Dis Res Ctr Excellence, Baltimore, MD USA

[7] UCL, Dept Clin Neurosci, London, England

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 15期

关键词：

apathy; hallucinations; depression; anxiety; Parkinson's disease; TRANSCRANIAL MAGNETIC STIMULATION; QUALITY STANDARDS SUBCOMMITTEE; DOUBLE-BLIND; RATING-SCALES; DIFFERENTIAL-DIAGNOSIS; VISUAL HALLUCINATIONS; PRACTICE PARAMETER; ANXIETY DISORDERS; AMERICAN-ACADEMY; PHYSICAL FATIGUE;

D O I：

10.1002/mds.22589

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuropsychiatric symptoms are common in Parkinson's disease, even at the earliest stages. and have important consequences for quality of life and daily functioning, are associated with increased carer burden and increased risk for nursing home admission. In addition to cognitive impairment, a wide range of neuropsychiatric symptoms have been reported. In this article, the epidemiology, clinical course, disagnosis, and management of some of the most common neuropsychiatric symptoms in PD are discussed: depression, anxiety, apathy, fatigue, and psychotic symptoms. Although much is known regarding the prevalence and course of these symptoms, the empirical evidence for how to manage these symptoms is limited at best. There is thus an urgent need for systematic studies for the pharmacological and non-pharmacological management of these symptoms. (C) 2009 Movement Disorder Society

引用

页码：2175 / 2186

页数：12

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