Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides

The development of carbamoyl chlorides as synthons for various amide-containing molecules and heterocycles has been summarized and discussed in this review article. Carbamoyl chlorides can participate in a diverse range of transition metal-catalyzed transformations including radical initiated reactions and cross-coupling and annulation reaction modes as well as C-H functionalization to access amide-functionalized organic frameworks having extensive applications in pharmaceutical and natural product synthesis. This review mainly highlights the advancements of carbamoyl chlorides as a powerful synthetic tool in transition-metal catalyzed reactions over the last two decades. In addition, transition-metal catalyzed reactions of their corresponding structural analogs, carbamoyl fluorides and cyanides, with respect to their chemical behavior are also briefly reviewed.