Urinary metabolites of gallic acid in rats and their radical-scavenging effects on 1,1-diphenyl-2-picrylhydrazyl radical

被引：63
|
作者：
Yasuda, T [1 ]
Inaba, A [1 ]
Ohmori, M [1 ]
Endo, T [1 ]
Kubo, S [1 ]
Ohsawa, K [1 ]
机构：
[1] Tohoku Pharmaceut Univ, Dept Phytochem, Aoba Ku, Sendai, Miyagi 9818558, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 10期
关键词：
D O I：
10.1021/np0000421
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
As a part of our studies on the metabolism of natural compounds, gallic acid was orally administered to rats. The urinary metabolites were analyzed by high-performance liquid chromatography, and their structures were determined to be pyrogallol (M1), pyrogallol-1-O-beta -D-glucuronide (M2), 4-O-methylgallic acid-3-O-sulfate (M3), 2-O-methylpyrogallol-1-O-beta -D-glucuronide (M4), 2-O-methylpyrogallol (M5), 4-O-methylgallic acid (M6), and unchanged gallic acid on the basis of chemical and spectral data. The radical scavenging effects of gallic acid and its urinary metabolites were evaluated using 1,1-diphenyl-apicrylhydrazyl radical.
引用
收藏
页码：1444 / 1446
页数：3
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