Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides

被引：10
|
作者：
Alfredo Garcia-Carrillo, Mario [1 ]
Guzman, Angel [1 ]
Diaz, Eduardo [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 20期
关键词：
N-Tosylhydrazones; Heteroaromatic sulfides; Diazocompounds; Imidazo[1,2-a]pyridines; Thieno[2,3-b]pyridines; MUSCARINIC RECEPTOR ANTAGONISTS; SULFUR BOND FORMATION; C-S; DIAZO-COMPOUNDS; ARYL HALIDES; STRAIGHTFORWARD SYNTHESIS; BIOLOGICAL-ACTIVITY; CARBONYL-COMPOUNDS; ANTIULCER AGENTS; BORONIC ACIDS;
D O I：
10.1016/j.tetlet.2017.04.021
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal free coupling of heteroaromatic N-tosylhydrazones with thiols is presented. A convenient synthetic route to synthesize heteroaryl N-tosylhydrazones is also showed. Valuable thioethers with pyrroles, pyridines, thieno[2,3-b]pyridines, imidazo[1,2-a]pyridines, and 6H-thieno[2,3-b]pyrroles derivatives were synthesized in good yields. This coupling reaction can be carried out in a one-pot fashion and scaled up to the gram scale by using heteroaryl aldehydes, without the need to isolate the Ntosylhydrazone. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1952 / 1956
页数：5
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