Gastroesophageal reflux and Barrett's esophagus: a pathway to esophageal adenocarcinoma

被引：24
|
作者：
Schlottmann, Francisco [1 ,2 ]
Molena, Daniela [3 ]
Patti, Marco G. [1 ,4 ]
机构：
[1] Univ N Carolina, Dept Surg, 4030 Burnett Womack Bldg,101 Manning Dr,CB 7081, Chapel Hill, NC 27599 USA
[2] Univ Buenos Aires, Hosp Aleman Buenos Aires, Dept Surg, Buenos Aires, DF, Argentina
[3] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA
[4] Univ N Carolina, Dept Med, Chapel Hill, NC 27515 USA
来源：
UPDATES IN SURGERY | 2018年 / 70卷 / 03期
关键词：
Gastroesophageal reflux disease; Barrett's esophagus; Metaplasia; Low-grade dysplasia; High-grade dysplasia; Esophageal adenocarcinoma; RISK-FACTORS; NEOPLASTIC PROGRESSION; GRADE DYSPLASIA; METAANALYSIS; EXPRESSION; CANCER; METAPLASIA; EPITHELIUM; ACID; BILE;
D O I：
10.1007/s13304-018-0564-y
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The incidence of esophageal adenocarcinoma (EAC) has increased significantly in Western countries. The rising prevalence of gastroesophageal reflux disease (GERD) and obesity has played a major role in the increasing numbers of EAC. Approximately 10-15% of patients with GERD will develop Barrett's esophagus (BE). This metaplastic transformation is due to the chronic injury produced by repeated reflux episodes and involves genetic mutations that can lead to a malignant transformation. Ultimately, the development of EAC is characterized by the sequence BE metaplasia-dysplasia-invasive carcinoma.
引用
收藏
页码：339 / 342
页数：4
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