Hierarchical construction of a mechanically stable peptide-graphene oxide hybrid hydrogel for drug delivery and pulsatile triggered release in vivo

被引：145
|
作者：
Wu, Junhua [1 ,2 ]
Chen, Aiping [2 ]
Qin, Meng [1 ]
Huang, Rong [2 ]
Zhang, Guang [3 ]
Xue, Bin [1 ]
Wei, Jiwu [2 ]
Li, Ying [4 ]
Cao, Yi [1 ]
Wang, Wei [1 ]
机构：
[1] Nanjing Univ, Dept Phys, Natl Lab Solid State Microstruct, Nanjing 210093, Jiangsu, Peoples R China
[2] Nanjing Univ, Sch Med, Nanjing 210093, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Gulou Sch Clin Med, Affiliated Drum Tower Hosp, Nanjing 210046, Jiangsu, Peoples R China
[4] Nanjing Univ Informat Sci & Technol, Jiangsu Key Lab Atmospher Environm Monitoring & P, Sch Environm Sci & Engn, Dept Chem, Nanjing 210044, Jiangsu, Peoples R China
来源：
NANOSCALE | 2015年 / 7卷 / 05期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
CROSS-LINKING APPROACH; ON-DEMAND RELEASE; SUPRAMOLECULAR HYDROGELS; BIORESPONSIVE HYDROGELS; BIOMEDICAL APPLICATIONS; SUSTAINED-RELEASE; DESIGN; NANOPARTICLES; NANOCOMPOSITES; ENCAPSULATION;
D O I：
10.1039/c4nr05798h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The design of hydrogels with controllable drug-release properties remains challenging. Here we report a hydrogel made of hierarchical graphene oxide sheets and peptide assemblies for on-demand drug release. The hydrogel possesses high drug-sustainability and the release of drugs can be precisely and remotely controlled through external stimuli.
引用
收藏
页码：1655 / 1660
页数：6
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