Can the acute-phase reactant proteins be used as cancer biomarkers?

被引：0
|
作者：
Pang, Wei Wei [2 ]
Abdul-Rahman, Puteri Shafinaz [1 ,2 ]
Wan-Ibrahim, Wan Izlina [1 ]
Hashim, Onn Haji [1 ,2 ]
机构：
[1] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Ctr Prote Res, Kuala Lumpur 50603, Malaysia
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2010年 / 25卷 / 01期
关键词：
Acute-phase reactant proteins; Biomarker; Cancer; Diagnosis; Serum; DIFFERENCE GEL-ELECTROPHORESIS; POTENTIAL SERUM BIOMARKER; SQUAMOUS-CELL CARCINOMA; PANCREATIC-CANCER; PLASMA-LEVELS; CARCINOEMBRYONIC ANTIGEN; ABUNDANCE PROTEINS; PROTEOMIC ANALYSIS; INSULIN-RECEPTOR; LECTIN DETECTION;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The association between the acute-phase reactant proteins (APRPs) and cancer has long been established. There have been numerous reports correlating altered levels of various APRPs with different types of cancers. However, researchers are often quick to dismiss the use of these APRPs as potential biomarkers for the diagnosis and monitoring of cancer because alterations in APRP concentrations are observed in a wide range of diseases. Recent progress in proteomics studies which profiled the serum proteins of cancer patients and those of normal individuals indicated that the altered APRP expressions were different for distinct types, subtypes, and even stages of cancer. Interestingly, these data are in agreement with those observed earlier using immunochemical and biochemical assays. In view of this compelling association of different patterns of APRPs with various types of cancers and in an apparent shift of paradigm, we present in this review some indications that APRP fingerprinting may be used as complementary cancer biomarkers. (Int J Biol Markers 2010: 25: 1-11)
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页码：1 / 11
页数：11
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