The Heck reaction under ball-milling conditions

被引：99
|
作者：
Tullberg, E
Peters, D
Frejd, T
机构：
[1] Lund Univ, Dept Organ & Bioorgan Chem 1, SE-22100 Lund, Sweden
[2] NeueoSearch A S, DK-2750 Ballerup, Denmark
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2004年 / 689卷 / 23期
关键词：
palladium catalysed Heck-couplings using ball-mill grinding;
D O I：
10.1016/j.jorganchem.2004.06.045
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis of unsaturated unnatural amino acids according to the Heck-Jeffery protocol using a ball-milling procedure is presented. NOE data recorded on the products confirm that the Z-isomer is formed. This type of mechano-chemistry provides an efficient, "solvent free" and reliable method for the synthesis of substituted dehydroalanines. These conditions provide patterns of reactivity complementary to conventional procedures. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：3778 / 3781
页数：4
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