Long-term intake of CocoanOX attenuates the development of hypertension in spontaneously hypertensive rats

被引：21
|
作者：
Quinones, M. [2 ]
Sanchez, D. [2 ]
Muguerza, B. [3 ]
Moulay, L. [3 ]
Laghi, S. [3 ]
Miguel, M. [1 ,2 ]
Aleixandre, A. [2 ]
机构：
[1] CSIC, Inst Fermentac Ind, Madrid 28006, Spain
[2] U Complutense, Fac Med, Dpto Farmacol, Madrid 28040, Spain
[3] Natraceut Grp, Valencia 46930, Spain
来源：
FOOD CHEMISTRY | 2010年 / 122卷 / 04期
关键词：
Antihypertensive activity; Cocoa; Polyphenols; Spontaneously hypertensive rats; BLOOD-PRESSURE; CARDIOVASCULAR RISK; FLAVONOID INTAKE; RICH COCOA; POWDER; HEALTH; (-)-EPICATECHIN; METAANALYSIS; MORTALITY; HUMANS;
D O I：
10.1016/j.foodchem.2010.03.059
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We have evaluated the effect of the long-term intake of a cocoa powder, with high concentration of polyphenols, named CocoanOX (CCX), on the development of hypertension of spontaneously hypertensive rats (SHR). Systolic blood pressure was measured weekly in the rats, from the 6th to 24th week of life, by the tail cuff method. The development of hypertension was attenuated in the groups treated with captopril or CCX. The antihypertensive effect was more accentuated in the group treated with captopril, and it was paradoxically more accentuated in the group treated with the lowest dose of CCX than in the other CCX groups. The arterial blood pressure increased in the treated SHR when the corresponding antihypertensive treatment was removed. Both, CCX and the standard cocoa, improved the aorta endothelial function in the SHR. In conclusion, CCX could be used as a functional food ingredient with antihypertensive activity. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1013 / 1019
页数：7
相关论文
共 50 条
  • [1] Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats
    Sipola, M
    Finckenberg, P
    Santisteban, J
    Korpela, R
    Vapaatalo, H
    Nurminen, ML
    [J]. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2001, 52 (04): : 745 - 754
  • [2] Long-term intake of egg white hydrolysate attenuates the development of hypertension in spontaneously hypertensive rats
    Miguel, Marta
    Lopez-Fandino, Rosina
    Ramos, Mercedes
    Aleixandre, Amaya
    [J]. LIFE SCIENCES, 2006, 78 (25) : 2960 - 2966
  • [3] Effect of long-term intake of cocoanox on the arterial blood pressure and endothelial function of spontaneously hypertensive rats
    Quiflones, M.
    Sdnchez, D.
    Moulay, L.
    Muguerza, B.
    Miguel, M.
    Aleixandre, A.
    [J]. JOURNAL OF HYPERTENSION, 2008, 26 : S185 - S185
  • [4] Long-term intake of an aqueous seed extract of Fraxinus excelsior L. attenuates the development of hypertension in spontaneously hypertensive rats
    Lopez Carreras, N.
    Fernandez Vallinas, S.
    Miguel, M.
    Aleixandre, A.
    [J]. PROCEEDINGS OF THE 6TH EUROPEAN CONGRESS OF PHARMACOLOGY, 2013, : 67 - 70
  • [5] LONG-TERM TREATMENT WITH CLONIDINE DURING THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS
    SMITH, LJ
    SUSSMAN, AM
    SERRA, M
    BUCCAFUSCO, JJ
    [J]. RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 1985, 47 (03): : 457 - 460
  • [6] Effects of long-term intake of edible oils on hypertension and myocardial and aortic remodelling in spontaneously hypertensive rats
    Aguila, MB
    Silva, SPS
    Pinheiro, AR
    Mandarim-De-Lacerda, CA
    [J]. JOURNAL OF HYPERTENSION, 2004, 22 (05) : 921 - 929
  • [7] Long-Term Treatment of Young Spontaneously Hypertensive Rats with Quercetin Partially Prevented Development of Hypertension
    Tabacekova, M.
    Toeoek, J.
    Zemancikova, A.
    Parohova, J.
    Vrankova, S.
    [J]. KIDNEY & BLOOD PRESSURE RESEARCH, 2012, 35 (02): : 102 - 102
  • [8] Long-Term Low Intensity Physical Exercise Attenuates Heart Failure Development in Aging Spontaneously Hypertensive Rats
    Pagan, Luana U.
    Damatto, Ricardo L.
    Cezar, Marcelo D. M.
    Lima, Aline R. R.
    Bonomo, Camila
    Campos, Dijon H. S.
    Gomes, Mariana J.
    Martinez, Paula F.
    Oliveira, Silvio A., Jr.
    Gimenes, Rodrigo
    Rosa, Camila M.
    Guizoni, Daniele M.
    Moukbel, Yasmin C.
    Cicogna, Antonio C.
    Okoshi, Marina P.
    Okoshi, Katashi
    [J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2015, 36 (01) : 61 - 74
  • [9] Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats
    Li, Wen-xing
    Kong, Xiang
    Zhang, Jun-xiu
    Yang, Jie-ren
    [J]. FOOD & FUNCTION, 2013, 4 (03) : 453 - 460
  • [10] Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats
    Lataro, Renata M.
    Silva, Carlos A. A.
    Tefe-Silva, Cristiane
    Prado, Cibele M.
    Salgado, Helio C.
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2015, 28 (10) : 1201 - 1208
12345