Conformation and dynamics of single DNA molecules in parallel-plate slit microchannels

被引：146

作者：

Chen, YL ^{[1
]}

Graham, MD

de Pablo, JJ

Randall, GC

Gupta, M

Doyle, PS

机构：

[1] Univ Wisconsin, Dept Biol & Chem Engn, Madison, WI 53703 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

PHYSICAL REVIEW E | 2004年 / 70卷 / 06期

关键词：

D O I：

10.1103/PhysRevE.70.060901

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

The conformation and diffusion of a single DNA molecule confined between two parallel plates are examined using both single molecule experiments and Brownian dynamics simulations accounting for hydrodynamic interactions. The degree of chain stretching and the diffusivity are characterized as a function of the chain confinement and the channel geometry. Good agreement is found between the simulations, experiments, and scaling theory predictions.

引用

页数：4

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