Prior exposure to MK-801 sensitizes rats to ethanol-induced conditioned taste aversion

被引：0
|
作者：
Bienkowski, P
Koros, E
Piasecki, J
Kostowski, W
机构：
[1] Inst Psychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, PL-02957 Warsaw, Poland
[2] Warsaw Med Sch, Dept Expt & Clin Pharmacol, PL-00527 Warsaw, Poland
来源：
ALCOHOL AND ALCOHOLISM | 1998年 / 33卷 / 02期
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D O I：
暂无
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Pretreatment with an uncompetitive NMDA receptor antagonist, dizocilpine [(+)MK-801; six daily injections of 0.1 or 0.2 mg/kg, i.p.] significantly enhanced subsequent 1.5 g/kg ethanol-induced conditioned taste aversion (CTA). In a control experiment, dizocilpine (0.05-0.2 mg/kg) produced only a marginal CTA. Thus, pre-exposure to low, non-aversive doses of MK-801 may sensitize rats to the aversive stimulus effects of ethanol.
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页码：116 / 120
页数：5
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