Comparison of the inhibition of the cytosolic phospholipase A2-mediated arachidonic acid release by several indole-2-carboxylic acids and 3-(pyrrol-2-yl)propionic acids in bovine and in human platelets

被引：0

作者：

Lehr, M ^{[1
]}

Elfringhoff, AS ^{[1
]}

机构：

[1] Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany

来源：

ARCHIV DER PHARMAZIE | 2000年 / 333卷 / 09期

关键词：

indole-2-carboxylic acids; 3-(pyrrol-2-yl)propionic acids; cytosolic phospholipase A(2) inhibition; bovine platelets; human platelets;

D O I：

10.1002/1521-4184(20009)333:9<312::AID-ARDP312>3.3.CO;2-P

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The inhibition of the cytosolic phospholipase A(2) (cPLA(2))-mediated arachidonic acid release by several indole-2-carboxylic acids and 3-(pyrrol-2-yl)propionic acids was measured intact human platelets using calcium ionophore A23817 as stimulant. The comparison of the obtained data with the inhibition data evaluated with bovine platelets showed that analogous results were obtained with both cell types.

引用

页码：312 / 314

页数：3

共 28 条

[1] Structure-activity relationship studies of 1-substituted 3-dodecanoylindole-2-carboxylic acids as inhibitors of cytosolic phospholipase A2-mediated arachidonic acid release in intact platelets
Griessbach, K
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Lehr, M
ARCHIV DER PHARMAZIE, 2003, 335 (11-12) : 547 - 555
[2] 3-(octadecanoylaminomethyl)indole-2-carboxylic acid derivatives and 1-methyl-3-octadecanoylindole-2-carboxyl acid as inhibitors of cytosolic phospholipase A(2)
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[3] Cytosolic (85 kDa) phospholipase A2-mediated release of arachidonic acid regulates cellular proliferation
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[4] 3-(3,5-dimethyl-4-octadecanoylpyrrol-2-yl)propionic acids as inhibitors of 85 kDa cytosolic phospholipase A(2)
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ARCHIV DER PHARMAZIE, 1996, 329 (11) : 483 - 488
[5] Structure-activity relationship studies of 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A2α-mediated arachidonic acid release in intact platelets:: variation of the keto moiety
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[6] The β1-integrin cytosolic domain optimizes phospholipase A2-mediated arachidonic acid release required for NIH-3T3 cell spreading
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[7] Novel indole-2-carboxylic acid linked 3-phenyl-2-alkoxy propanoic acids: Synthesis, molecular docking and in vivo antidiabetic studies
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[8] Novel indole-2-carboxylic acid linked 3-phenyl-2-alkoxy propanoic acids: Synthesis, molecular docking and in vivo antidiabetic studies
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MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (04) : 745 - 759
[9] 1-(3-Biaryloxy-2-oxopropyl)indole-5-carboxylic Acids and Related Compounds as Dual Inhibitors of Human Cytosolic Phospholipase A2α and Fatty Acid Amide Hydrolase
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[10] MECHANISMS OF PHOSPHOLIPASE-A2-MEDIATED RELEASE OF OMEGA-3-FATTY-ACIDS IN HUMAN NEUTROPHILS
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CONQUER, J
FASEB JOURNAL, 1992, 6 (04): : A1054 - A1054

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