A measure of heart rate variability is sensitive to orthostatic challenge in women with chronic fatigue syndrome

被引:31
|
作者
Yamamoto, Y
LaManca, JJ
Natelson, BH
机构
[1] UMD, New Jersey Med Sch, Dept Neurosci, E Orange, NJ 07018 USA
[2] Univ Tokyo, Grad Sch Educ, Educ Physiol Lab, Tokyo 1130033, Japan
关键词
chronic fatigue syndrome; postural orthostatic tachycardia syndrome; head up tilt; heart rate variability; fractal;
D O I
10.1177/153537020322800206
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The use of symptoms generated by head up tilt (HUT) is not a useful tool in identifying chronic fatigue syndrome (CFS). We investigated whether heart rate variability (HRV) assessed early during HUT might be useful. A sample of 46 female subjects (24 with CFS and 22 sedentary, age-matched healthy controls; CON) who had exhibited no difference in time to syncope during tilt was examined for HRV responses to 10 min of 70degrees HUT after 5 min of baseline in the supine position. HRV data were analyzed by the method of coarse graining spectral analysis. Variables compared between groups included mean and standard deviation (SDRRI) of RR intervals (RRI), amplitudes of low- (A(LF); 0.04-0.15 Hz) and high-frequency (A(HF); >0.15 Hz) harmonic as well as aperiodic, fractal (A(FR); 1/f(beta)) spectral components, the spectral exponent beta, and the difference in these values between baseline and HUT for each subject. In the supine baseline, only mean RRI was significantly (P < 0.01) lower in CFS than in CON. During HUT, however, mean RRI (P < 0.01), SDRRI (P < 0.01), A(HF) (P < 0.05), and A(FR) (P < 0.01) were significantly lower in CFS than in CON. When the difference in values between baseline and HUT for each subject was examined, only the difference for A(FR) (DeltaA(FR)) Was significantly (P < 0.01) lower in CFS than in CON, suggesting that A(FR) is a disease-specific response of HRV to HUT. When a cut-off level was set to DeltaA(FR) = -2.7 msec, the sensitivity and the specificity in differentiating CFS from controls were 90% and 72%, respectively. The data suggest that a decrease in aperiodic fractal component of HRV in response to HUT can be used to differentiate patients with CFS from CON.
引用
收藏
页码:167 / 174
页数:8
相关论文
共 50 条
  • [1] Poststroke alterations in heart rate variability during orthostatic challenge
    Rodriguez, Joel
    Blaber, Andrew Philip
    Kneihsl, Markus
    Trozic, Irhad
    Ruedl, Rebecca
    Green, David A.
    Broadbent, James
    Xu, Da
    Rossler, Andreas
    Hinghofer-Szalkay, Helmut
    Fazekas, Franz
    Goswami, Nandu
    [J]. MEDICINE, 2017, 96 (14)
  • [2] Validity Of A Heart Rate Monitor For Heart Rate Variability Analysis During An Orthostatic Challenge
    Soto-Catalan, Christian
    Martin, David
    Leclerc, Suzanne
    Comtois, Alain Steve
    [J]. MEDICINE & SCIENCE IN SPORTS & EXERCISE, 2022, 54 (09) : 100 - 100
  • [3] Comparison of heart rate variability in patients with chronic fatigue syndrome and controls
    A. Yataco
    H. Talo
    P. Rowe
    D. A. Kass
    R. D. Berger
    H. Calkins
    [J]. Clinical Autonomic Research, 1997, 7 : 293 - 297
  • [4] Comparison of heart rate variability in patients with chronic fatigue syndrome and controls
    Yataco, A
    Talo, H
    Rowe, P
    Kass, DA
    Berger, RD
    Calkin, H
    [J]. CLINICAL AUTONOMIC RESEARCH, 1997, 7 (06) : 293 - 297
  • [5] HEART-RATE-VARIABILITY AS A MEASURE OF AUTONOMIC FUNCTION IN PATIENTS WITH FIBROMYALGIA (FM) AND CHRONIC FATIGUE SYNDROME (CFS)
    CLAUW, DJ
    RADULOVIC, D
    HESHMAT, Y
    BARBEY, JT
    [J]. ARTHRITIS AND RHEUMATISM, 1995, 38 (06): : R25 - R25
  • [6] Speckleplethysmographic (SPG) Estimation of Heart Rate Variability During an Orthostatic Challenge
    Dunn, Cody E.
    Monroe, Derek C.
    Crouzet, Christian
    Hicks, James W.
    Choi, Bernard
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [7] Speckleplethysmographic (SPG) Estimation of Heart Rate Variability During an Orthostatic Challenge
    Cody E. Dunn
    Derek C. Monroe
    Christian Crouzet
    James W. Hicks
    Bernard Choi
    [J]. Scientific Reports, 9
  • [8] Good reproducibility of heart rate variability after orthostatic challenge in patients with a history of acute coronary syndrome
    Schaefer, Daniela
    Nil, Markus
    Herzig, David
    Eser, Prisca
    Saner, Hugo
    Wilhelm, Matthias
    [J]. JOURNAL OF ELECTROCARDIOLOGY, 2015, 48 (04) : 696 - 702
  • [9] Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
    Rosa María Escorihuela
    Lluís Capdevila
    Juan Ramos Castro
    María Cleofé Zaragozà
    Sara Maurel
    José Alegre
    Jesús Castro-Marrero
    [J]. Journal of Translational Medicine, 18
  • [10] Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
    Maria Escorihuela, Rosa
    Capdevila, Lluis
    Ramos Castro, Juan
    Cleofe Zaragoza, Maria
    Maurel, Sara
    Alegre, Jose
    Castro-Marrero, Jesus
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2020, 18 (01)