Challenges in vaccinating infants born to mothers taking immunoglobulin biologicals during pregnancy

被引：34

作者：

Ling, Juejing ^{[1
]}

Koren, Gideon ^{[1
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Dept Pharmaceut Sci, Toronto, ON M5G 1X8, Canada

来源：

EXPERT REVIEW OF VACCINES | 2016年 / 15卷 / 02期

关键词：

Immunoglobulins; biologicals; anti-TNF therapy; rituximab; newborn; prenatal exposure; immune system; infection; vaccination; INFLAMMATORY-BOWEL-DISEASE; TNF-ALPHA THERAPY; B-CELL LYMPHOMA; PLACENTAL-TRANSFER; 1ST TRIMESTER; BREAST-MILK; NEUROMYELITIS-OPTICA; RITUXIMAB THERAPY; ADALIMUMAB LEVELS; MATERNAL SERUM;

D O I：

10.1586/14760584.2016.1115351

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While immunoglobulin biologicals are increasingly used during pregnancy, there have been concerns on the immune function and vaccination of infants born to mothers taking immunoglobulin biologicals. In addition to the detection of biologicals in cord blood, cases of severe neonatal neutropenia and fatal dissemination of Bacillus Calmette-Guerin (BCG) have been reported. With increasing number of infants exposed to immunoglobulin biologicals in utero, there is a need to address the challenges in vaccinating these infants. This review summarizes the available evidence to discuss the issues of immunoglobulin biological exposure in utero, neonatal immune function, long-term immune development, and the challenges and strategies of vaccinating newborns and infants who were born to mothers taking biologicals during pregnancy.

引用

页码：239 / 256

页数：18

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