Silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides: divergent synthesis of indolizines and pyrroles

被引：81
|
作者：
Meng, Xianyu [1 ]
Liao, Peiqiu [1 ]
Liu, Jianquan [1 ]
Bi, Xihe [1 ,2 ,3 ]
机构：
[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China
[2] State Key Lab, Tianjin 300071, Peoples R China
[3] Inst Elemento Organ Chem, Tianjin 300071, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 80期
关键词：
ONE-POT SYNTHESIS; FUNCTIONALIZED INDOLIZINES; OLIGOSUBSTITUTED PYRROLES; CYCLOADDITION; CYCLOISOMERIZATION;
D O I：
10.1039/c4cc04905e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Divergent syntheses of indolizines and 2,4-disubstituted pyrroles by the silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides arereported. These methods provide an effective route to highly functionalized indolizines and 2,4-disubstituted pyrroles in good to excellent yields. The 2,4-disubstituted pyrroles are synthesized by an unprecedented regioselective [3+2] cycloaddition of terminal alkynes with isocyanides.
引用
收藏
页码：11837 / 11839
页数：3
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