Autonomous Prostate Segmentation in 2D B-Mode Ultrasound Images

Prostate brachytherapy is a treatment for prostate cancer; during the planning of the procedure, ultrasound images of the prostate are taken. The prostate must be segmented out in each of the ultrasound images, and to assist with the procedure, an autonomous prostate segmentation algorithm is proposed. The prostate contouring system presented here is based on a novel superpixel algorithm, whereby pixels in the ultrasound image are grouped into superpixel regions that are optimized based on statistical similarity measures, so that the various structures within the ultrasound image can be differentiated. An active shape prostate contour model is developed and then used to delineate the prostate within the image based on the superpixel regions. Before segmentation, this contour model was fit to a series of point-based clinician-segmented prostate contours exported from conventional prostate brachytherapy planning software to develop a statistical model of the shape of the prostate. The algorithm was evaluated on nine sets of in vivo prostate ultrasound images and compared with manually segmented contours from a clinician, where the algorithm had an average volume difference of 4.49 mL or 10.89%.