Individual difference in drug metabolism and disposition:: Toxicological significance of genotypes and phenotypes of S-mephenytoin 4′-hydroxylase (CYP2C19)

We examined the relationship between the genetic polymorphism of CYP2C19 and metabolism of omeprazole in order to assess the severity and to predict the outcome of poisoning for forensic and clinical toxicology. The genotypes observed were CYP2C19*1A (wild type), CYP2C19*2 (ml), and CYP2C19*3 (m2). The omeprazole hydroxylation index of the wild-type was -1.15, whereas for the hetero-type it was -0.78, and homo-mutated type 1.22. The genotype of CYP2C19 correlated with the phenotype. The present results proved that genotyping assays of drug metabolizing enzymes are of great value in toxicological significance. (C) 2003 Elsevier Science B.V. All rights reserved.