The evolving role of radiotherapy in non-small cell lung cancer

被引：109
|
作者：
Brown, Sean [1 ]
Banfill, Kathryn [1 ,2 ]
Aznar, Marianne C. [1 ,2 ,3 ]
Whitehurst, Philip [4 ]
Finn, Corinne Faivre [1 ,2 ]
机构：
[1] Christie NHS Fdn Trust, Manchester, Lancs, England
[2] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester Canc Res Ctr, Div Canc Sci, Manchester, Lancs, England
[3] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England
[4] Christie NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, CMPE, Manchester, Lancs, England
来源：
BRITISH JOURNAL OF RADIOLOGY | 2019年 / 92卷 / 1104期
关键词：
STEREOTACTIC ABLATIVE RADIOTHERAPY; BODY RADIATION-THERAPY; INTENSITY-MODULATED RADIOTHERAPY; LOCAL CONSOLIDATIVE THERAPY; CONCURRENT CHEMOTHERAPY; COMPUTED-TOMOGRAPHY; CONFORMAL RADIOTHERAPY; ADAPTIVE RADIOTHERAPY; RESIDUAL DISEASE; DOSE-ESCALATION;
D O I：
10.1259/bjr.20190524
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Lung cancer is the most commonly diagnosed cancer and biggest cause of cancer mortality worldwide with non-small cell lung cancer (NSCLC) accounting for most cases. Radiotherapy (RT) plays a key role in its management and is used at least once in over half of patients in both curative and palliative treatments. This narrative review will demonstrate how the evolution of RT for NSCLC has been underpinned by improvements in RT technology. These improvements have facilitated geometric individualization, increasingly accurate treatment and now offer the ability to deliver truly individualized RT. In this review, we summarize and discuss recent developments in the field of advanced RT in early stage, locally advanced and metastatic NSCLC. We highlight limitations in current approaches and discuss future potential treatment strategies for patients with NSCLC.
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页数：15
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