Division of labour in ESCRT complexes

被引：6

作者：

Bassereau, Patricia ^{[1
]}

机构：

[1] Inst Curie, Lab PhysicoChim Curie, F-75248 Paris 05, France

来源：

NATURE CELL BIOLOGY | 2010年 / 12卷 / 05期

关键词：

MEMBRANE DEFORMATION; TRAFFICKING; BIOGENESIS; ENDOSOMES; CURVATURE; MECHANISM; TENSION;

D O I：

10.1038/ncb0510-422

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Formation of multivesicular bodies (MVBs) from endosomes or budding of enveloped virus such as HIV-I from the plasma membrane require the ESCRT (endosomal sorting complex required for transport) complexes. An in vitro reconstitution assay unambiguously identifies the function of each ESCRT complex in the sequential events of MVB morphogenesis, from cargo clustering and membrane bud formation to sequestration of cargoes in vesicles, and fission of the vesicles into the lumen of the endosome.

引用

页码：422 / 423

页数：2

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