MPID: MHC-peptide Interaction Database for sequence-structure-function information on peptides binding to MHC molecules

被引：21
|
作者：
Govindarajan, KR
Kangueane, P
Tan, TW
Ranganathan, S [1 ]
机构：
[1] Natl Univ Singapore, Dept Biochem, Singapore 119260, Singapore
[2] Natl Univ Singapore, Dept Biol Sci, Singapore 119260, Singapore
[3] Nanyang Technol Univ, MPE, NCSV, Bioinformat Grp, Singapore 639798, Singapore
来源：
BIOINFORMATICS | 2003年 / 19卷 / 02期
关键词：
D O I：
10.1093/bioinformatics/19.2.309
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the first step in T-cell mediated immune response. To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). A user-friendly web interface and query tools will facilitate the development of predictive algorithms for MHC-peptide binding from a structural viewpoint.
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收藏
页码：309 / 310
页数：2
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