Iron Deficiency in Obesity and after Bariatric Surgery

被引:34
|
作者
Bjorklund, Geir [1 ]
Peana, Massimiliano [2 ]
Pivina, Lyudmila [3 ,4 ]
Dosa, Alexandru [5 ]
Aaseth, Jan [6 ]
Semenova, Yuliya [3 ,4 ]
Chirumbolo, Salvatore [7 ,8 ]
Medici, Serenella [2 ]
Dadar, Maryam [9 ]
Costea, Daniel-Ovidiu [5 ]
机构
[1] Council Nutr & Environm Med, Toften 24, N-8610 Mo I Rana, Norway
[2] Univ Sassari, Dept Chem & Pharm, Via Vienna 2, I-07100 Sassari, Italy
[3] Semey Med Univ, Dept Neurol Ophthalmol & Otolaryngol, Semey 071400, Kazakhstan
[4] Semey Med Univ, CONEM Kazakhstan Environm Hlth & Safety Res Grp, Semey 071400, Kazakhstan
[5] Ovidius Univ Constanta, Fac Med, Constanta 900470, Romania
[6] Innlandet Hosp Trust, Res Dept, N-2380 Brumunddal, Norway
[7] Univ Verona, Dept Neurosci Biomed & Movement Sci, I-37134 Verona, Italy
[8] CONEM Sci Secretary, I-37134 Verona, Italy
[9] Agr Res Educ & Extens Org AREEO, Razi Vaccine & Serum Res Inst, Karaj 31975148, Iran
关键词
obesity; iron deficiency; iron metabolism; bariatric surgery; iron supplement; Y GASTRIC BYPASS; SOLUBLE TRANSFERRIN RECEPTOR; SUBCUTANEOUS ADIPOSE-TISSUE; APPARENTLY HEALTHY-MEN; WEIGHT-LOSS; INSULIN-RESISTANCE; OXIDATIVE STRESS; SERUM FERRITIN; METABOLIC SURGERY; AMERICAN SOCIETY;
D O I
10.3390/biom11050613
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Iron deficiency (ID) is particularly frequent in obese patients due to increased circulating levels of acute-phase reactant hepcidin and adiposity-associated inflammation. Inflammation in obese subjects is closely related to ID. It induces reduced iron absorption correlated to the inhibition of duodenal ferroportin expression, parallel to the increased concentrations of hepcidin. Obese subjects often get decreased inflammatory response after bariatric surgery, accompanied by decreased serum hepcidin and therefore improved iron absorption. Bariatric surgery can induce the mitigation or resolution of obesity-associated complications, such as hypertension, insulin resistance, diabetes mellitus, and hyperlipidemia, adjusting many parameters in the metabolism. However, gastric bypass surgery and sleeve gastrectomy can induce malabsorption and may accentuate ID. The present review explores the burden and characteristics of ID and anemia in obese patients after bariatric surgery, accounting for gastric bypass technique (Roux-en-Y gastric bypass-RYGB) and sleeve gastrectomy (SG). After bariatric surgery, obese subjects' iron status should be monitored, and they should be motivated to use adequate and recommended iron supplementation.
引用
收藏
页数:15
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