Sunitinib Alone or after Nephrectomy in Renal Cancer

被引:5
|
作者
Kondoh, Chihiro N. [1 ]
Miura, Yuji [1 ]
Yamanaka, Takeharu [2 ]
机构
[1] Toranomon Gen Hosp, Tokyo, Japan
[2] Yokohama City Univ, Sch Med, Yokohama, Kanagawa, Japan
来源
NEW ENGLAND JOURNAL OF MEDICINE | 2018年 / 379卷 / 19期
关键词
D O I
10.1056/NEJMc1811532
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To the Editor: In the CARMENA (Cancer du Rein Metastatique Nephrectomie et Antiangiogeniques) trial, Mejean et al. (Aug. 2 issue)(1) determine the noninferiority of sunitinib alone, as compared with nephrectomy followed by sunitinib, on the basis of the observation that the 95% confidence interval for the hazard ratio of death did not exceed 1.20 (the noninferiority margin for the trial). This conclusion was derived from the second interim analysis, in which a criterion for statistical significance was defined according to the O'Brien-Fleming boundary; this boundary was not met, but the trial was terminated early because of slow enrollment. The confidence . . .
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收藏
页码:1877 / 1877
页数:1
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