Osteosarcoma is the most prevalent type of primary malignant bone tumor. Inhibitor of growth 4 (ING4) has been demonstrated to function as a tumor suppressor through multiple pathways, and is its expression is understood to be suppressed or reduced in various malignancies. The present study aimed to investigate the expression of ING4 and to determine its prognostic value in osteosarcoma tissue. Formalin-fixed, paraffin-embedded tissue microarrays were analyzed, and contained 41 osteosarcoma specimens and 11 normal bone tissue specimens with duplicate cores. ING4 expression was evaluated by immunohistochemical staining. The association between ING4 expression in the osteosarcoma and normal bone tissues was analyzed, in addition to the association between ING4 expression and Enneking classification of the osteosarcoma tissues. A significant statistical difference was observed in the ING4 immunohistochemical staining score between the osteosarcoma and normal bone tissues (P<0.001). Furthermore, a significant negative correlation was detected between the ING4 immunohistochemical staining scores and the Enneking classification results of the 41 osteosarcoma tissues (P=0.002). Low expression of ING4 was observed in the osteosarcoma specimens, and this reduced expression of ING4 was negatively correlated with Enneking classification. Thus, the results of the present study indicate that ING4 may serve as a promising prognostic marker in osteosarcoma.
机构:Kyung Hee Univ, Dept Pathol, Kyung Hee Med Ctr, Coll Med, Seoul 130702, South Korea
Won, Kyu Yeoun
Park, Hye-Rim
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Hallym Univ, Dept Pathol, Coll Med, Seoul, South KoreaKyung Hee Univ, Dept Pathol, Kyung Hee Med Ctr, Coll Med, Seoul 130702, South Korea
Park, Hye-Rim
Park, Yong-Koo
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Kyung Hee Univ, Dept Pathol, Kyung Hee Med Ctr, Coll Med, Seoul 130702, South KoreaKyung Hee Univ, Dept Pathol, Kyung Hee Med Ctr, Coll Med, Seoul 130702, South Korea
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Harbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Yuan, J.
Han, Y. -L.
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Harbin Med Univ, Dept Microbiol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Han, Y. -L.
Wang, T. -Y.
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Harbin Med Univ, Dept Microbiol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Wang, T. -Y.
Wu, S.
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Harbin Med Univ, Dept Microbiol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Wu, S.
Tong, L.
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Harbin Med Univ, Dept Microbiol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Tong, L.
Lin, L. -X.
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Harbin Med Univ, Dept Microbiol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Lin, L. -X.
Li, M.
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Harbin Med Univ, Chinese Ctr Dis Control & Prevent, Ctr Endem Dis Control, Inst Iodine Deficiency Disorders, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Li, M.
Wei, L. -L.
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Harbin Med Univ, Dept Microbiol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Wei, L. -L.
Zhong, Z. -H.
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Harbin Med Univ, Dept Microbiol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Zhong, Z. -H.
Zhang, G. -M.
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Harbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
Zhang, G. -M.
Wang, Y.
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Harbin Med Univ, Dept Microbiol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China