Genomic Influences on Susceptibility and Severity of Rheumatoid Arthritis

被引：12

作者：

Knevel, Rachel ^{[1
,2
,3
,4
]}

Huizinga, Tom W. J. ^{[3
]}

Kurreeman, Fina ^{[3
]}

机构：

[1] Brigham & Womens Hosp, Div Genet, Raychaudhuri Lab, 77 Ave Louis Pasteur,2th Floor,Room 255, Boston, MA 02115 USA

[2] Harvard Med Sch, 25 Shattuck St, Boston, MA 02115 USA

[3] Leiden Univ, Med Ctr, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

[4] Broad Inst, 415 Main St, Cambridge, MA 02142 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2017年 / 43卷 / 03期

关键词：

Genomics; Genetics; Rheumatoid arthritis; Severity; Phenotype; RAPID RADIOGRAPHIC PROGRESSION; JOINT DESTRUCTION; GENETIC-VARIANTS; RISK MODELS; ASSOCIATION; DAMAGE; HLA; LOCI; HETEROGENEITY; POLYMORPHISM;

D O I：

10.1016/j.rdc.2017.04.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetics in rheumatoid arthritis (RA) has moved from the finding of HLA-shared epitope decades ago toward the understanding of the role of HLA in RA and the findings of similar to 100 additional genetic risk variants for disease susceptibility as well as several risk variants for severe disease. These findings increased our understanding of RA abnormality. Still, the mechanisms by which many of the variants exhibit their effect are not yet understood.

引用

页码：347 / +

页数：17

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