Neutralizing immunity against SARS-CoV-2 Omicron BA.1 by infection and vaccination

被引：7
|
作者：
Duan, Li-Jun [1 ]
Jiang, Wen-Gu [2 ]
Wang, Zhuang-Ye [3 ]
Yao, Lin [1 ]
Zhu, Ka-Li [1 ]
Meng, Qing-Chuan [4 ]
Wang, Bao-Shan [5 ]
Li, Li-Bo [2 ]
Wang, Guo-Lin [1 ]
Ma, Mai-Juan [1 ]
机构：
[1] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China
[2] Jining Ctr Dis Control & Prevent, Jining, Peoples R China
[3] Jining Ctr Dis Control & Prevent, Dezhou, Peoples R China
[4] Ningjin Cty Community Hlth Serv Ctr, Dezhou, Peoples R China
[5] Decheng Dist Ctr Dis Control & Prevent, Dezhou, Peoples R China
来源：
ISCIENCE | 2022年 / 25卷 / 09期
基金：
北京市自然科学基金;
关键词：
RESPONSES; VACCINES;
D O I：
10.1016/j.isci.2022.104886
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The emergence of the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant has raised questions regarding resistance to neutralizing antibodies elicited by natural infection or immunization. We examined the neutralization activity of sera collected from previously SARS-CoV-2-infected individuals and SARS-CoV-2 naive individuals who received BBIBP-CorV or CoronaVac to BA.1 and the earlier variants Alpha, Beta, and Delta. Both sera from convalescent patients over three months after infection and two-dose BBIBP-CorV or CoronaVac vaccine recipients barely inhibited BA.1, less effectively neutralized Beta and Delta, and moderately neutralized Alpha. However, administering a single dose of BBIBP-CorV or CoronaVac in previously infected individuals or a third dose booster vaccination of BBIBP-CorV or CoronaVac in previously vaccinated individuals enhances neutralizing activity against BA.1 and other variants, albeit with a lower antibody titer for BA.1. Our data suggest that a booster vaccination is important to broaden neutralizing antibody responses against the variants.
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页数：14
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