A recessive CCD mutation in RyR1 (V4849I) increases voltage-gated Ca2+ release and SR Ca2+ release flux following homozygous expression in dyspedic myotubes.

被引:0
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作者
Lyfenko, AD
Avila, G
Schuhmeier, RP
Melzer, W
Dirksen, RT
机构
[1] Univ Rochester, Rochester, NY 14627 USA
[2] IPN, CINVESTAV, Mexico City 07738, DF, Mexico
[3] Univ Ulm, D-89069 Ulm, Germany
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Q6 [生物物理学];
学科分类号
071011 ;
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页码:488A / 488A
页数:1
相关论文
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  • [1] Expression of RyR3, but not RyR1, produces Ca2+ sparks in dyspedic myotubes
    Ward, C
    Castillo, D
    Protasi, F
    Wang, Y
    Chen, S
    Schneider, M
    Allen, P
    [J]. BIOPHYSICAL JOURNAL, 1999, 76 (01) : A386 - A386
  • [2] Reduced voltage-gated Ca2+ release in the absence of SR Ca2+ leak in myotubes derived from heterozygous 14895T RyR1 knock-in mice.
    Loy, Ryan E.
    Goonasekera, Sanjeewa A.
    Zvaritch, Elena
    Depreux, Frederic
    Seidman, Christine
    Seidman, Jon
    MacLennan, David H.
    Dirksen, Robert T.
    [J]. BIOPHYSICAL JOURNAL, 2007, : 311A - 311A
  • [3] Ca2+-induced Ca2+ release (CICR) in dyspedic (RyR1 null) skeletal myotubes induced by DHPR β2a
    Sheridan, DC
    Mortenson, L
    Coronado, R
    [J]. BIOPHYSICAL JOURNAL, 2002, 82 (01) : 77A - 77A
  • [4] Inactivation of Ca2+ release channels (ryanodine receptors RyR1 and RyR2) with rapid steps in [Ca2+] and voltage
    Laver, DR
    Lamb, GD
    [J]. BIOPHYSICAL JOURNAL, 1998, 74 (05) : 2352 - 2364
  • [5] Restoration of depolarization-induced Ca2+ release by frog α-ryanodine receptor (α-RyR) heterologously expressed in 1B5 dyspedic mouse myotubes.
    Kashiyama, T
    Murayama, T
    Allen, PD
    Ogawa, Y
    [J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, 91 : 96P - 96P
  • [6] Concentration dependence of caffeine-induced Ca2+ release in dyspedic skeletal myotubes transfected with ryanodine receptor isoform-1 (RYR1) cDNAs
    Booms, P.
    Duke, A. M.
    Steele, D.
    Shaw, M. A.
    Carpenter, D.
    Robinson, R. L.
    Halsall, P. J.
    Allen, P. D.
    Yang, T.
    Iles, D. E.
    Hopkins, P. M.
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 2009, 103 (02) : 315 - 315
  • [7] The I4897T central core disease mutation in RyR-1 severely compromises voltage-ated SR calcium release following expression in dyspedic myotubes.
    Avila, G
    O'Brien, JJ
    Dirksen, RT
    [J]. BIOPHYSICAL JOURNAL, 2001, 80 (01) : 385A - 385A
  • [8] Reduced threshold for spontaneous Ca2+ release is a common defect in RyR1 mutations associated with MH and CCD
    Chen, Wenqian
    Grawunder, Greg
    Wang, Ruiwu
    Zhang, Lin
    MacLennan, David H.
    Chen, S. R. Wanye
    [J]. BIOPHYSICAL JOURNAL, 2007, : 262A - 262A
  • [9] The skeletal muscle ryanodine receptor (RyR1) promotes L-type Ca2+ channel expression is cultured skeletal myotubes.
    Dirksen, RT
    O'Connell, KMS
    Avila, G
    [J]. BIOPHYSICAL JOURNAL, 2000, 78 (01) : 370A - 370A
  • [10] NO donors block [125I]Apocalmodulin binding to the skeletal muscle Ca2+ release channel (RyR1)
    Rodney, G
    Zhang, ZZ
    Strasburg, GM
    Reid, MB
    Hamilton, SL
    [J]. BIOPHYSICAL JOURNAL, 1999, 76 (01) : A301 - A301