False-positive IgM antibody tests for cytomegalovirus in patients with acute Epstein-Barr virus infection

被引：45
|
作者：
Deyi, YM [1 ]
Goubau, P [1 ]
Bodéus, M [1 ]
机构：
[1] Univ Catholique Louvain, Virol Unit, Dept Microbiol, B-1200 Brussels, Belgium
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2000年 / 19卷 / 07期
关键词：
D O I：
10.1007/s100960000317
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The diagnosis of acute cytomegalovirus (CMV) infection is frequently based on a positive IgM result. False-positive reactions due to interfering infections may exist. Between August 1998 and May 1999, 62 patients were found to be IgM positive and IgG negative with the Axsym assay (Abbott, Ger many). Serological testing for Epstein-Barr virus (EBV) was performed in these patients to detect any cross-reactivity due to acute mononucleosis. Additionally, the results of the CMV Axsym was evaluated in 40 patients with acute EBV infection. The results suggest that the CMV-IgM Axsym assay shows a lack of specificity due to acute EBV infection. Precautions must be taken when CMV-IgM Axsym results are interpreted. It seems necessary to confirm equivocal results with another technique and to take into account other clinical and biological observations.
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收藏
页码：557 / 560
页数：4
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