Prevent Effects of Lactobacillus Fermentum HY01 on Dextran Sulfate Sodium-Induced Colitis in Mice

被引:79
|
作者
Chen, Xiaoyong [1 ,2 ,3 ]
Zhao, Xin [3 ]
Wang, Hongwei [1 ,2 ]
Yang, Zelin [4 ]
Li, Jian [5 ]
Suo, Huayi [1 ,2 ]
机构
[1] Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China
[2] Chongqing Engn Res Ctr Reg Food, Chongqing 400715, Peoples R China
[3] Chongqing Univ Educ, Chongqing Collaborat Innovat Ctr Funct Food, Chongqing 400067, Peoples R China
[4] Chongqing Proviencial Ctr Anim Dis Control & Prec, Chongqing 401120, Peoples R China
[5] Southwest Univ Nationalities, Coll Life Sci & Technol, Chengdu 610041, Peoples R China
来源
NUTRIENTS | 2017年 / 9卷 / 06期
关键词
traditional fermented yak yogurt; Lactobacillus fermentum; intestinal function; colitis; dextran sulfate sodium; LACTIC-ACID BACTERIA; ULCERATIVE-COLITIS; YAK MILK; MOUSE MODEL; INFLAMMATION; STRAINS; EXPRESSION; PRODUCTS; REVEALS; DISEASE;
D O I
10.3390/nu9060545
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The aim of this study is to assess the preventive effects of Lactobacillus fermentum HY01 (LF-HY01) to dextran sulfate sodium induced-colitis. We observed the ratio of colon weight to its length, colon pathological changes, and the concentrations of pro-inflammatory factors (IFN-gamma, IL-12, TNF alpha, and IL-6) in serum. We also took account of the protein levels of I kappa B alpha, NF-kappa B p65, iNOS, and COX-2, and we measured the best effects of different doses of Lactobacillus fermentum HY01 (low dose group was 10(9) CFU/kg.bw, high dose group was 10(10) CFU/kg.bw) on dextran sulfate sodium-induced colitis mice. The results were remarkable, suggesting that Lactobacillus fermentum HY01 had significant preventive effects in dextran sulfate sodium induced-colitis; simultaneously, the high dose group showed the best results among other groups. It can effectively alleviate the shortened colon length, reduce the ratio of colon weight to its length, reduce edema, inflammatory cells infiltration, and colon mucosa injury, and play an important role in the down-regulation of concentrations of pro-inflammatory factors (IFN-gamma, IL-12, TNF alpha, and IL-6). Above all, Lactobacillus fermentum HY01 shows promising prevention for I kappa B alpha degradation, inhibition of NF-kappa B p65 phosphorylation cascades, and decreases the protein levels of iNOS and COX-2 as well.
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页数:12
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