Chemically modified DNA nanostructures for drug delivery

被引：21

作者：

Wang, Yuang ^{[1
,2
]}

Lu, Xuehe ^{[1
,2
]}

Wu, Xiaohui ^{[2
,3
]}

Li, Yan ^{[2
]}

Tang, Wantao ^{[1
,2
]}

Yang, Changping ^{[1
,2
]}

Liu, Jianbing ^{[2
,3
]}

Ding, Baoquan ^{[1
,2
,3
]}

机构：

[1] Zhengzhou Univ, Henan Inst Adv Technol, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Nanosystemand Hierarch Fabricat, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

INNOVATION | 2022年 / 3卷 / 02期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

STABLE GENE NANOPARTICLES; EFFICIENT CONSTRUCTION; ORIGAMI NANOSTRUCTURES; PHOSPHOROTHIOATE DNA; SYSTEMIC DELIVERY; RNA INTERFERENCE; FOLDING DNA; MOLECULE; SIRNA; RESOLUTION;

D O I：

10.1016/j.xinn.2022.100217

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Based on predictable, complementary base pairing, DNA can be artificially pre-designed into versatile DNA nanostructures of well-defined shapes and sizes. With excellent addressability and biocompatibility, DNA nanostructures have been widely employed in biomedical research, such as bio-sensing, bio-imaging, and drug delivery With the development of the chemical biology of nucleic acid, chemically modified nucleic acids are also gradually developed to construct multifunctional DNA nanostructures. In this review, we summarize the recent progress in the construction and functionalization of chemically modified DNA nanostructures. Their applications in the delivery of chemotherapeutic drugs and nucleic acid drugs are highlighted. Furthermore, the remaining challenges and future prospects in drug delivery by chemically modified DNA nanostructures are discussed.

引用

页数：11

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