Neurofibromatosis type I (NF1), a tumor suppressor gene, is synergistically activated by RUNX1, C/EBPαa and ETS2 and specifically repressed by the t(8;21) fusion protein in acute myeloid leukemia.

被引：0
|
作者：
Yang, GY
Khalaf, W
Clapp, WD
Hiebert, SW
机构：
[1] Vanderbilt Univ, Nashville, TN USA
[2] Indiana Univ, Indianapolis, IN 47405 USA
来源：
BLOOD | 2004年 / 104卷 / 11期
关键词：
D O I：
10.1182/blood.V104.11.2551.2551
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2551
引用
收藏
页码：699A / 699A
页数：1
相关论文
共 9 条
  • [1] Epigenetic regulation of the neurofibromatosis-1 tumor suppressor in t(8:21)-containing acute myeloid leukemia.
    Yang, GY
    Khalaf, W
    Van de Locht, L
    Jansen, JH
    Thompson, MA
    Van Der Reijden, B
    Gutmann, DH
    Delwel, R
    Clapp, DW
    Hiebert, S
    BLOOD, 2003, 102 (11) : 856A - 856A
  • [2] Tumor Suppressor RASSF2 Is Downregulated By The RUNX1-ETO Fusion Protein In t(8;21)+ Acute Myeloid Leukemia
    Stoner, Samuel A.
    Dekelver, Russell
    Lo, Miao-Chia
    Zhang, Dong-Er
    BLOOD, 2013, 122 (21)
  • [3] Complex rearrangement in acute myeloid leukemia M2 with RUNX1/RUNX1T1 fusion involving chromosomes 8, 17 and 21
    Mishra, Shiba Ranjan
    Rawal, Leena
    Othman, Moneeb A. K.
    Thatai, Atul
    Sarkar, Aditi
    Lal, Vandana
    Bhattacharya, Saurabh Kumar
    MOLECULAR CYTOGENETICS, 2021, 14 (01)
  • [4] Complex rearrangement in acute myeloid leukemia M2 with RUNX1/RUNX1T1 fusion involving chromosomes 8, 17 and 21
    Shiba Ranjan Mishra
    Leena Rawal
    Moneeb A. K. Othman
    Atul Thatai
    Aditi Sarkar
    Vandana Lal
    Saurabh Kumar Bhattacharya
    Molecular Cytogenetics, 14
  • [5] Effects of c-KIT mutations on expression of the RUNX1/RUNX1T1 fusion transcript in t(8;21)-positive acute myeloid leukemia patients
    Park, Sang Hyuk
    Chi, Hyun-Sook
    Cho, Young-Uk
    Jang, Seongsoo
    Park, Chan-Jeoung
    LEUKEMIA RESEARCH, 2013, 37 (07) : 784 - 789
  • [6] The t(8;21) fusion protein, AML1-ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia
    Linggi, B
    Müller-Tidow, C
    van de Locht, L
    Hu, M
    Nip, J
    Serve, H
    Berdel, WE
    van der Reijden, B
    Quelle, DE
    Rowley, JD
    Cleveland, J
    Jansen, JH
    Pandolfi, PP
    Hiebert, SW
    NATURE MEDICINE, 2002, 8 (07) : 743 - 750
  • [7] The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia
    Bryan Linggi
    Carsten Müller-Tidow
    Louis van de Locht
    Ming Hu
    John Nip
    Hubert Serve
    Wolfgang E. Berdel
    Bert van der Reijden
    Dawn E. Quelle
    Janet D. Rowley
    John Cleveland
    Joop H. Jansen
    Pier Paolo Pandolfi
    Scott W. Hiebert
    Nature Medicine, 2002, 8 : 743 - 750
  • [8] The t(8;21) fusion protein RUNX1-ETO downregulates PKM2 in acute myeloid leukemia cells
    Yan, Jin-Song
    Li, Yi-Dong
    Liu, Su-Hui
    Yin, Qian-Qian
    Liu, Xin-Yi
    Xia, Li
    Lu, Ying
    LEUKEMIA & LYMPHOMA, 2017, 58 (08) : 1985 - 1988
  • [9] The t(8;21) fusion protein, AML-1/ETO, specifically represses transcription of the p14ARF tumor suppressor in acute myeloid leukemias.
    Linggi, B
    Müller-Tidow, C
    van de Locht, L
    Nip, J
    Serve, H
    Berdel, WE
    van der Reijden, B
    Quelle, DE
    Rowley, JD
    Jansen, JH
    Hiebert, SW
    BLOOD, 2001, 98 (11) : 834A - 834A
1