Biogenic biocompatible silver nanoparticles: a promising antibacterial agent

The biogenic synthesis of silver nanoparticles (AgNPs) are gaining attention because they are eco-friendly, non-hazardous, economical and devoid of the drawbacks of physicochemical processes. Biogenic approaches for synthesizing nanoparticles (NPs) using plant leaves, seeds, bark, stems, fruits, roots and flowers are highly cost-effective compared to other methods. Silver (Ag) has been used since ancient times, but biogenic AgNPs have only been made in the last few decades. They have been employed primarily in the food and pharmaceutical industries as antimicrobials and antioxidants. Recent studies have confirmed that many molecules present in different bacteria, including Escherichia coli, Staphylococcus aureus, Citrobacter koseri, Bacillus cereus, Salmonella typhi, Klebsipneumoniaoniae, Vibrio parahaemolyticus, Pseudomonas Aeruginosa, are bound to the AgNPs and can be inhibited using multifaceted mechanisms like AgNPs inter inside the cells, free radicals, ROS generation and modulate transduction pathways. Recent breakthroughs in nanobiotechnology-based therapeutics have opened up new possibilities for fighting microorganisms. Thus, in particular, biogenic AgNPs as powerful antibacterial agents have gained much interest. Surface charge, colloidal state, shape, concentration and size are the most critical physicochemical characteristics that determine the antibacterial potential of AgNPs. Based on this review, it can be stated that AgNPs could be made better in terms of their potency, durability, accuracy, biosecurity and compatibility.