BRCA1 and BRCA2 -: breast cancer susceptibility genes

被引：30
|
作者：
Hofmann, W
Schlag, PM
机构：
[1] Robert Roessle Hosp, Dept Surg & Surg Oncol, D-13122 Berlin, Germany
[2] Max Delbruck Ctr Mol Med, Dept Tumor Genet, D-13092 Berlin, Germany
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2000年 / 126卷 / 09期
关键词：
BRCA1; BRCA2; breast cancer; genetic predisposition;
D O I：
10.1007/s004320000140
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Genetic predisposition is responsible for 5%-10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibility genes BRCA1 (breast cancer gene 1) and BRCA2 and the current genetic testing for mutations in both genes are the basis for estimating disease risks for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer.
引用
收藏
页码：487 / 496
页数：10
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