SAFETY AND PHARMACOKINETICS OF A NOVEL HUMAN MONOCLONAL ANTIBODY DIRECTED AGAINST THE E2 GLYCOPROTEIN OF HEPATITS C VIRUS (MBL-HCV1) IN HEALTHY VOLUNTEERS

被引：2
|
作者：
Leav, B. A. [1 ]
Sloan, S. [1 ]
Blair, B. M. [1 ]
Cheslock, P. [1 ]
Knauber, M. [1 ]
Ambrosino, D. M. [1 ]
Molrine, D. C. [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Boston, MA 02125 USA
来源：
JOURNAL OF HEPATOLOGY | 2010年 / 52卷
关键词：
D O I：
10.1016/S0168-8278(10)60283-8
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：S118 / S118
页数：1
相关论文
共 50 条
  • [1] A NOVEL HUMAN MONOCLONAL ANTIBODY DIRECTED AGAINST THE E2 GLYCOPROTEIN OF HEPATITIS C VIRUS (HCV) PREVENTS INFECTION IN CHIMPANZEES
    Blair, B. M.
    Broering, T. J.
    Babcock, G. J.
    Szabo, G.
    Finberg, R. W.
    Cheslock, P. S.
    Knauber, M.
    Leav, B. A.
    Lanford, R.
    Purcell, R. H.
    Ambrosino, D. M.
    Molrine, D. C.
    JOURNAL OF HEPATOLOGY, 2009, 50 : S381 - S381
  • [2] Epitope mapping of human antibody response against HCV/E2 glycoprotein by generation of monoclonal recombinant Fabs
    Burioni, R
    Bugli, F
    Di Campli, C
    Desogus, A
    Manzin, A
    Gasbarrini, A
    Gasbarrini, G
    Fadda, G
    JOURNAL OF HEPATOLOGY, 2000, 32 : 46 - 46
  • [3] Identification and Characterization of Broadly Neutralizing Human Monoclonal Antibodies Directed against the E2 Envelope Glycoprotein of Hepatitis C Virus
    Broering, Teresa J.
    Garrity, Kerry A.
    Boatright, Naomi K.
    Sloan, Susan E.
    Sandor, Frantisek
    Thomas, William D., Jr.
    Szabo, Gyongyi
    Finberg, Robert W.
    Ambrosino, Donna M.
    Babcock, Gregory J.
    JOURNAL OF VIROLOGY, 2009, 83 (23) : 12473 - 12482
  • [4] PERI-TRANSPLANT TREATMENT WITH ANTI-HCV E2 HUMAN MONOCLONAL ANTIBODY MBL-HCV1 IN COMBINATION WITH A PROTEASE INHIBITOR RESULTS IN UNDETECTABLE HCV RNA IN THE EARLY POST-TRANSPLANT PERIOD
    Curry, M. P.
    Smith, L.
    Chung, R. T.
    Schiano, T. D.
    Chapman, W. C.
    Mantry, P. S.
    Brown, K. A.
    Molrine, D. C.
    JOURNAL OF HEPATOLOGY, 2014, 60 (01) : S471 - S471
  • [5] Anti-hepatitis C virus E2 (HCV/E2) glycoprotein monoclonal antibodies and neutralization interference
    Sautto, Giuseppe
    Mancini, Nicasio
    Diotti, Roberta A.
    Solforosi, Laura
    Clementi, Massimo
    Burioni, Roberto
    ANTIVIRAL RESEARCH, 2012, 96 (01) : 82 - 89
  • [6] Characterization of antibody-mediated neutralization directed against the hypervariable region 1 of hepatitis C virus E2 glycoprotein
    Vieyres, Gabrielle
    Dubuisson, Jean
    Patel, Arvind H.
    JOURNAL OF GENERAL VIROLOGY, 2011, 92 : 494 - 506
  • [7] Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein
    Perotti, Mario
    Mancini, Nicasio
    Diotti, Roberta A.
    Tarr, Alexander W.
    Ball, Jonathan K.
    Owsianka, Ania
    Adair, R.
    Patel, Arvind H.
    Clementi, Massimo
    Burioni, Roberto
    JOURNAL OF VIROLOGY, 2008, 82 (02) : 1047 - 1052
  • [8] Clinical evaluation of a human monoclonal antibody against the envelope protein (E2) of HCV for prevention of HCV infection
    Ilan, E
    Zauberman, A
    Graham, N
    Nussbaum, O
    Terkieltaub, D
    Galun, E
    Terrault, N
    Eren, R
    Dagan, S
    ANTIVIRAL RESEARCH, 2004, 62 (02) : A52 - A52
  • [9] Clinical evaluation of a human monoclonal antibody against the envelope protein (E2) of HCV for prevention of HCV infection
    Dagan, S
    Eren, R
    Graham, N
    Nussbaum, O
    Terkieltaub, D
    Terrault, N
    Tur-Kaspa, R
    Lurie, Y
    Safadi, R
    Akerman, Z
    Galun, E
    JOURNAL OF HEPATOLOGY, 2004, 40 : 24 - 24
  • [10] Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein
    Owsianka, Ania M.
    Tarr, Alexander W.
    Keck, Zhen-Yong
    Li, Ta-Kai
    Witteveldt, Jeroen
    Adair, Richard
    Foung, Steven K. H.
    Ball, Jonathan K.
    Patel, Arvind H.
    JOURNAL OF GENERAL VIROLOGY, 2008, 89 : 653 - 659
12345