Neoadjuvant Endocrine Therapy for Breast Cancer

被引：1
|
作者：
Chawla, Jane S. [1 ]
Ma, Cynthia X. [1 ,2 ]
Ellis, Matthew J. [1 ,2 ]
机构：
[1] Washington Univ, Dept Med, Div Oncol, St Louis, MO 63110 USA
[2] Washington Univ, Siteman Canc Ctr, St Louis, MO 63110 USA
来源：
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2010年 / 19卷 / 03期
关键词：
Breast cancer; Estrogen receptor; Neoadjuvant endocrine therapy; Genomics; Relapse risk; FIRST-LINE THERAPY; POSTMENOPAUSAL WOMEN; AROMATASE INHIBITOR; PRIMARY CHEMOTHERAPY; RANDOMIZED-TRIAL; PHASE-III; TAMOXIFEN; LETROZOLE; ANASTROZOLE; COMBINATION;
D O I：
10.1016/j.soc.2010.04.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neoadjuvant endocrine therapy improves surgical outcomes for postmenopausal women with bulky hormone receptor positive breast cancer. Recent studies indicate that this approach may also be used in the management of smaller tumors with the hope of predicting outcomes from adjuvant endocrine manipulation. Neoadjuvant endocrine therapy provides a unique opportunity to identify molecular predictors of endocrine responsiveness and agents that can be used in combination with endocrine therapy to improve tumor response and overcome endocrine resistance.
引用
收藏
页码：627 / +
页数：13
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