This paper presents a brief argument, based on a mechanistic approach, to show that radiation risk is linear with radiation dose from zero dose Lip. Similarities in cellular effects lead to the assumption of a common mechanism and the DNA double strand break is identified as the crucial radiation-induced lesion. A cancer model extends the cellular effects to the main radiation risk providing confirmation of the dose effect for cancer at low doses.
机构:
NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Bethesda, MD 20892 USAHelmholtz Zentrum Munchen, Inst Radiat Protect, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany
Little, Mark P.
Shore, Roy S.
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h-index: 0
机构:
NYU, Sch Med, 650 First Ave, New York, NY 10016 USAHelmholtz Zentrum Munchen, Inst Radiat Protect, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany
[J].
IRPA9 - 1996 INTERNATIONAL CONGRESS ON RADIATION PROTECTION / NINTH INTERNATIONAL CONGRESS OF THE INTERNATIONAL RADIATION PROTECTION ASSOCIATION, PROCEEDINGS, VOL 1,
1996,
: A17
-
A23
机构:
Faculté de Médecine, Centre Antoine Béclère, 45 rue des Saints-Pères, 75006 Paris, FranceFaculté de Médecine, Centre Antoine Béclère, 45 rue des Saints-Pères, 75006 Paris, France
Tubiana, M.
Masse, R.
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机构:
11 rue du Haras, Résidence Le Boqueteau, Acacias 2, 91240 Saint-Michel-sur-Orge, FranceFaculté de Médecine, Centre Antoine Béclère, 45 rue des Saints-Pères, 75006 Paris, France
Masse, R.
De Vathaire, F.
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h-index: 0
机构:
INSERM U 605. Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, FranceFaculté de Médecine, Centre Antoine Béclère, 45 rue des Saints-Pères, 75006 Paris, France
De Vathaire, F.
Averbeck, D.
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h-index: 0
机构:
Institut Curie, Laboratoire Raymond Latarjet, UMR2027 du CNRS, 91405 Orsay Cedex, FranceFaculté de Médecine, Centre Antoine Béclère, 45 rue des Saints-Pères, 75006 Paris, France
Averbeck, D.
Aurengo, A.
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机构:
Service Médecine Nucléaire, Hôpital Pitié-Salpêtrière, 75013 Paris, FranceFaculté de Médecine, Centre Antoine Béclère, 45 rue des Saints-Pères, 75006 Paris, France
机构:
STUK Radiat & Nucl Safety Author, Helsinki 00881, FinlandSTUK Radiat & Nucl Safety Author, Helsinki 00881, Finland
Salomaa, Sisko
Averbeck, Dietrich
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h-index: 0
机构:
IRSN PRP HOM, Inst Radioprotect & Surete Nucl, F-92262 Fontenay Aux Roses, FranceSTUK Radiat & Nucl Safety Author, Helsinki 00881, Finland
Averbeck, Dietrich
Ottolenghi, Andrea
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h-index: 0
机构:
Univ Pavia, Dept Phys, I-27100 Pavia, ItalySTUK Radiat & Nucl Safety Author, Helsinki 00881, Finland
Ottolenghi, Andrea
Sabatier, Laure
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机构:
Commissariat Energie Atom & Energies Alternat, CEA DSV IRCM, F-92265 Fontenay Aux Roses, FranceSTUK Radiat & Nucl Safety Author, Helsinki 00881, Finland