Applicability of the nearest-neighbour model for pseudoknot RNAs

被引：3
|
作者：
Satpathi, Sagar [1 ]
Endoh, Tamaki [1 ]
Sugimoto, Naoki [1 ,2 ]
机构：
[1] Konan Univ, Frontier Inst Biomol Engn Res FIBER, 7-1-20 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan
[2] Konan Univ, Grad Sch Frontiers Innovat Res Sci & Technol FIRS, 7-1-20 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 40期
基金：
日本学术振兴会;
关键词：
THERMODYNAMIC PARAMETERS; SECONDARY STRUCTURE; STABILITY; PREDICTION; JUNCTION;
D O I：
10.1039/d1cc07094k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The validity of the nearest-neighbour (NN) model was verified in an RNA pseudoknot (PK) structure. The thermodynamic parameters of the second hairpin stem (S2) region, which separates the PK from a hairpin structure, were monitored using CD and UV melting. Different PKs with identical NN base pairs in the S2 region exhibited similar thermodynamic parameters, highlighting the validity of the NN model in this RNA tertiary structure motif.
引用
收藏
页码：5952 / 5955
页数：5
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