OXA-24 Carbapenemase Gene Flanked by XerC/XerD-Like Recombination Sites in Different Plasmids from Different Acinetobacter Species Isolated during a Nosocomial Outbreak

被引：95

作者：

Merino, Maria ^{[1
]}

Acosta, Joshi ^{[2
]}

Poza, Margarita ^{[1
]}

Sanz, Francisca ^{[2
]}

Beceiro, Alejandro ^{[1
]}

Chaves, Fernando ^{[2
]}

Bou, German ^{[1
]}

机构：

[1] Complejo Hosp Univ A Coruna INIBIC, Microbiol Lab, La Coruna 15006, Spain

[2] Hosp 12 Octubre, Microbiol Serv, E-28041 Madrid, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 06期

关键词：

HYDROLYZING OXACILLINASE OXA-58; CLINICAL ISOLATE; BETA-LACTAMASE; BAUMANNII; RESOLUTION; GENOSPECIES-3; RESISTANCE; STABILITY; STRAINS;

D O I：

10.1128/AAC.01674-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A clinical strain of Acinetobacter calcoaceticus resistant to carbapenems was isolated from a blood culture sample from an inpatient in a hospital in Madrid (Spain) during a large outbreak of infection (affecting more than 300 inpatients), caused by a multidrug-resistant Acinetobacter baumannii clone. The carbapenem resistance in both the A. calcoaceticus and A. baumannii clones was due to a bla(OXA-24) gene harbored in different plasmids. The plasmids were fully sequenced, revealing the presence of site-specific recombination binding sites putatively involved in mobilization of the bla(OXA-24) gene. Comparison of plasmids contained in the two strains revealed possible horizontal transmission of resistance genes between the Acinetobacter species.

引用

页码：2724 / 2727

页数：4