Verruciform xanthoma of the scrotum in association with neurofibroma: a case report and a brief review of the literature

Verruciform xanthoma (VX) is a rare benign mucocutaneous lesion that typically presents as solitary asymptomatic verrucous growth. Histopathologic examination remains the cornerstone of diagnosis, which shows subepithelial lipid-laden foamy histiocytes associated with papillomatosis, parakeratosis, and dyskeratosis. Previous studies have reported oral cavity as the most common site of VX. However, extra oral cases have also been reported mainly on vulva, penis, and scrotum. Most of the previous studies of VX on scrotum have been reported in Japanese males and few in Causacian males. Here, we report a first case of scrotal VX in Chinese male occurring in a co-existence with neurofibroma of the trunk. We also present a brief review of the literature.