Total synthesis of (+)-cladospolide D

被引：4
|
作者：
Reddy, Chada Raji [1 ,2 ]
Dilipkumar, Uredi [1 ]
VIallesh, Kathe [1 ,2 ]
Latha, Bellamkonda [1 ]
Shravya, Ravula [1 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Div Nat Prod Chem, Hyderabad 500007, Andhra Pradesh, India
[2] Acad Sci & Innovat Res, New Delhi 110001, India
来源：
TETRAHEDRON-ASYMMETRY | 2016年 / 27卷 / 4-5期
关键词：
CLADOSPOLIDE-B; BIOLOGICAL EVALUATION; CLADOSPORIOIDES; METATHESIS; MACROLIDE; CATALYSTS; LACTONES; CROSS;
D O I：
10.1016/j.tetasy.2016.01.013
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The asymmetric total synthesis of cladospolide D, a natural 12-membered macrolide antibiotic, has been accomplished in 12-steps. Sharpless asymmetric dihydroxylation, Grubb's cross metathesis, and Shiina lactonization have been employed as the key reactions for the installation of the desired stereocenter and the construction of the macrolactone framework. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：222 / 225
页数：4
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