Targeting PTP4A3 phosphatase in ovarian cancer with the potent noncompetitive inhibitor JMS-631-053

被引：0
|
作者：
Lazo, John S.
Pekic, Paula
Cheung, Alex
McQueeney, Kelley
Salamoun, Joseph
Wipf, Peter
Landen, Charles N.
Sharlow, Elizabeth R.
机构：
来源：
CANCER RESEARCH | 2017年 / 77卷
关键词：
D O I：
10.1158/1538-7445.AM2017-3210
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3210
引用
收藏
页数：2
相关论文
共 25 条
  • [1] The Mechanism of Inhibition of the Undrugged Oncogenic Phosphatase PTP4A3 by a Novel Small Molecule JMS-053
    Garrott, Sharon R.
    Blanco, Isabella K.
    Tasker, Nikhil R.
    Rastelli, Ettore J.
    Sharlow, Elizabeth R.
    Wipf, Peter
    Lazo, John S.
    FASEB JOURNAL, 2019, 33
  • [2] Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer
    Lazo, John S.
    Sharlow, Elizabeth R.
    Cornelison, Robert
    Hart, Duncan J.
    Llaneza, Danielle C.
    Mendelson, Anna J.
    Rastelli, Ettore J.
    Tasker, Nikhil R.
    Landen, Charles N., Jr.
    Wipf, Peter
    BIOMOLECULES, 2021, 11 (07)
  • [3] Discovering potent PTP4A3 phosphatase small molecule inhibitors for colorectal cancer
    McQueeney, Kelley E.
    Salamoun, Joseph M.
    Handing, Kasia
    Boulton, Adam
    Sharlow, Elizabeth R.
    Bushweller, John H.
    Minor, Wladek
    Wipf, Peter
    Lazo, John S.
    FASEB JOURNAL, 2016, 30
  • [4] PTP4A3 phosphatase is a novel drug target for epithelial ovarian cancer.
    Cornelison, John Robert
    Rastelli, Ettore J.
    Hart, Duncan J.
    Mendelson, Anna J.
    Sharlow, Elizabeth R.
    Wipf, Peter
    Lazo, John S.
    CANCER RESEARCH, 2021, 81 (13)
  • [5] Targeting Ptp4a3 in Colon Tumorigenesis and Cancer Progression
    Zimmerman, M. W.
    Homanics, G. E.
    Lazo, J. S.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : 16 - 16
  • [6] Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase
    Lazo, John S.
    Isbell, Kelly N.
    Vasa, Sai Ashish
    Llaneza, Danielle C.
    Rastelli, Ettore J.
    Wipf, Peter
    Sharlow, Elizabeth R.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2023, 384 (03): : 429 - 438
  • [7] Small molecule PTP4A3 phosphatase inhibitors targeting acute myeloid leukemia
    Lazo, J.
    Tasker, N.
    Rastelli, E.
    Wipf, P.
    Sharlow, E.
    EUROPEAN JOURNAL OF CANCER, 2020, 138 : S55 - S56
  • [8] Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor
    Salamoun, Joseph M.
    McQueeney, Kelley E.
    Patil, Kalyani
    Geib, Steven J.
    Sharlow, Elizabeth R.
    Lazo, John S.
    Wipf, Peter
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 14 (27) : 6398 - 6402
  • [9] Next Generation Potent Cell-active Inhibitors of the Oncogenic PTP4A3 Phosphatase
    Blanco, Isabella K.
    Tasker, Nikhil R.
    Rastelli, Etttore J.
    Wipf, Peter
    Sherlow, Elizabeth R.
    Lazo, John S.
    FASEB JOURNAL, 2019, 33
  • [10] A PTP4A3 inhibitor reduces ovarian cancer dissemination and alters STAT3 and ERK activation.
    Lazo, John S.
    Isbell, Kelly N.
    Llaneza, Danielle C.
    Rastelli, Ettore J.
    Landen, Charles N.
    Wipf, Peter
    Sharlow, Elizabeth R.
    CANCER RESEARCH, 2022, 82 (12)
123