Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation

被引：194
|
作者：
Lee, BH [1 ]
Amon, A [1 ]
机构：
[1] MIT, Ctr Canc Res, Howard Hughes Med Inst, Cambridge, MA 02139 USA
来源：
SCIENCE | 2003年 / 300卷 / 5618期
关键词：
D O I：
10.1126/science.1081846
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The budding yeast Polo-like kinase Cdc5 was found to be instrumental in establishing the meiosis I chromosome segregation program. Cdc5 was required to phosphorylate and remove meiotic cohesin from chromosomes. Furthermore, in the absence of CDC5 kinetochores were bioriented during meiosis I, and Mam1, a protein essential for coorientation, failed to associate with kinetochores. Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5.
引用
下载
收藏
页码：482 / 486
页数：5
相关论文
共 50 条
  • [1] Analysis of Polo-like kinase Cdc5 in the meiosis recombination checkpoint
    Iacovella, Maria G.
    Daly, Catherine N.
    Kelly, Jamie-Sioux
    Michielsen, Adriana J.
    Clyne, Rosemary K.
    CELL CYCLE, 2010, 9 (06) : 1182 - 1193
  • [2] Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I
    Clyne, RK
    Katis, VL
    Jessop, L
    Benjamin, KR
    Herskowitz, I
    Lichten, M
    Nasmyth, K
    NATURE CELL BIOLOGY, 2003, 5 (05) : 480 - 485
  • [3] Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I
    Rosemary K. Clyne
    Vittorio L. Katis
    Lea Jessop
    Kirsten R. Benjamin
    Ira Herskowitz
    Michael Lichten
    Kim Nasmyth
    Nature Cell Biology, 2003, 5 : 480 - 485
  • [4] Polo kinase Cdc5 is a central regulator of meiosis I
    Attner, Michelle A.
    Miller, Matthew P.
    Ee, Ly-sha
    Elkin, Sheryl K.
    Amon, Angelika
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (35) : 14278 - 14283
  • [5] Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis
    Sourirajan, Anuradha
    Lichten, Michael
    GENES & DEVELOPMENT, 2008, 22 (19) : 2627 - 2632
  • [6] The polo-like kinase Cdc5 interacts with FEAR network components and Cdc14
    Rahal, Rami
    Amon, Angelika
    CELL CYCLE, 2008, 7 (20) : 3262 - 3272
  • [7] Functions and regulation of the Polo-like kinase Cdc5 in the absence and presence of DNA damage
    Botchkarev, Vladimir V., Jr.
    Haber, James E.
    CURRENT GENETICS, 2018, 64 (01) : 87 - 96
  • [8] Role in cytokinesis for Cdc5, the Polo like kinase in budding yeast
    Hardy, CF
    Woo, SH
    Bartholomew, CR
    MOLECULAR BIOLOGY OF THE CELL, 2000, 11 : 7A - 7A
  • [9] Functions and regulation of the Polo-like kinase Cdc5 in the absence and presence of DNA damage
    Vladimir V. Botchkarev
    James E. Haber
    Current Genetics, 2018, 64 : 87 - 96
  • [10] Generation of an inducible system to express polo-like kinase, Cdc5 as TAP fusion protein during meiosis in Saccharomyces cerevisiae
    Vaid, Rajni
    Dev, Kamal
    Lichten, Michael
    Sourirajan, Anuradha
    3 BIOTECH, 2016, 6
12345