Fluorescent Probe for Bisulfite/Sulfite Imaging in Mitochondria

被引：3

作者：

Jiang Na ^{[1
]}

Fan Jiangli ^{[1
]}

Zhang Shuai ^{[1
]}

Peng Xiaojun ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2014年 / 35卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Sulfite; Bisulfate ion; Mitochondria; Fluorescent imaging; HYDROGEN-SULFIDE; WATER;

D O I：

10.7503/cjcu20140542

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new type of pentamethine cyanine dye with bromo group at the central position Cy5-Br was designed and synthesized, and the structure is not reported as far as we know. Cy5-Br can identify SO2 derivatives bisulfite and sulfite with a good linear response. Furthermore, Cy5-Br has low cytotoxic to living cells, can localize in mitochondria, and image its bisulfite and sulfite ions concentration real-time change in living cells by the laser confocal fluorescence microscope.

引用

页码：2534 / 2541

页数：8

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