In Vitro Activity of ACH-702, a New Isothiazoloquinolone, against Nocardia brasiliensis Compared with Econazole and the Carbapenems Imipenem and Meropenem Alone or in Combination with Clavulanic Acid

The in vitro activities of ACH-702 and other antimicrobials against 30 Nocardia brasiliensis isolates were tested. The MIC(50) (MIC for 50% of the strains tested) and MIC(90) values of ACH-702 were 0.125 and 0.5 mu g/ml. The same values for econazole were 2 and 4 mu g/ml. The MIC(50) and MIC(90) values of imipenem and meropenem were 64 and >64 mu g/ml and 2 and 8 mu g/ml, respectively; the addition of clavulanic acid to the carbapenems had no effect.